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Paracrine and synaptic mechanisms underlying neural stem cell-mediated stroke recovery

  • Post author:
  • Post published:October 13, 2025
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Stem cell therapy holds promise for the almost million Americans yearly who suffer a stroke. Preclinical data have shown that human neural stem cells (hNSCs) aid recovery after stroke, resulting…

Continue ReadingParacrine and synaptic mechanisms underlying neural stem cell-mediated stroke recovery

Metabolic regulation of cardiac differentiation and maturation

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  • Post published:October 13, 2025
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Cells in the body take up nutrients from their environment and metabolize them in a complex set of biochemical reactions to generate energy and replicate. Control of these processes is…

Continue ReadingMetabolic regulation of cardiac differentiation and maturation

Assessing the mechanism by which the Bone Morphogenetic Proteins direct stem cell fate

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  • Post published:October 13, 2025
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Our goal is to use the mechanisms that generate neuronal networks to create neurons from stem cells, to either replace diseased and damaged tissue or as a source of material…

Continue ReadingAssessing the mechanism by which the Bone Morphogenetic Proteins direct stem cell fate

Innate Immune Regulation of Lung Alveolar Stem Cell Renewal in Mouse and Man

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  • Post published:October 13, 2025
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The lung, along with the skin and gut are the three organs in perpetual contact with our environment. The lung has evolved mechanisms for repairing injury due to exogenous noxious…

Continue ReadingInnate Immune Regulation of Lung Alveolar Stem Cell Renewal in Mouse and Man

A novel druggable mechanism to safeguard stem cell genome

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  • Post published:October 13, 2025
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Safeguarding the genome is essential for cells’ proper functions, and more importantly for safe and efficacious applications involving pluripotent stem cells and adult stem cells. However, how pluripotent or somatic…

Continue ReadingA novel druggable mechanism to safeguard stem cell genome

Generation of a functional thymus to induce immune tolerance to stem cell derivatives

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  • Post published:October 13, 2025
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Stem cell research offers the promise of replacing missing or damaged tissues in the treatment of disease. Stem-cell-derived transplants still face problems with rejection as in traditional organ transplants. Several…

Continue ReadingGeneration of a functional thymus to induce immune tolerance to stem cell derivatives

Molecular basis of plasma membrane characteristics reflecting stem cell fate potential

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  • Post published:October 13, 2025
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Stem cells generate mature, functional cells after proteins on the cell surface interact with cues from the environment encountered during development or after transplantation. Thus, these cell surface proteins are…

Continue ReadingMolecular basis of plasma membrane characteristics reflecting stem cell fate potential

Defining links between chromatin state and developmental competence

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  • Post published:October 13, 2025
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This proposal aims to define fundamental mechanisms that underlie the production of human pancreas and liver cells. The proposed research seeks to advance the development of stem cell-based therapies for…

Continue ReadingDefining links between chromatin state and developmental competence

Promoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes

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  • Post published:October 13, 2025
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Degenerative joint disease, also known as osteoarthritis, currently affects more than 20 million people in the USA alone, making articular cartilage restoration one of the major priorities in medicine. Articular…

Continue ReadingPromoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes

Promoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes

  • Post author:
  • Post published:October 13, 2025
  • Post category:

Degenerative joint disease, also known as osteoarthritis, currently affects more than 20 million people in the USA alone, making articular cartilage restoration one of the major priorities in medicine. Articular…

Continue ReadingPromoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes
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