High-Throughput Discovery of Embryo Formation Factors Using Stem Cell-Based Human Embryo Models

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Research Objective To integrate emulsion microfluidics-based encapsulation with AI-powered imaging to develop a high-throughput pipeline for stem cell-based embryo models. Impact We will overcome key bottlenecks to drive breakthroughs in…

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Dissecting the cellular and molecular interactions between embryo and endometrium during human implantation.

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Research Objective This research will define the dynamic mechanisms of human embryo implantation by integrating live imaging, spatial multi-omics, and gene editing in physiologically relevant stem cell-based models. Impact This…

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Next generation stem cell transplantation approaches for pediatric neurodegenerative disorders

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Research Objective A complete methodology for high efficiency, minimal toxicity hematopoietic stem cell transplantation for treatment of pediatric neurodegenerative disorders. Impact Improve treatment and outcomes for patients with neurodegenerative disorders…

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Development of in vitro and in vivo functional human synthetic kidney organoid (hSKO) model as a platform technology for kidney research

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Research Objective Development of a human stem cell-derived, spatially-patterned, mature and functional human synthetic kidney organoid (hSKO) model as a platform technology for basic and translational kidney research. Impact Lack…

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Genetic and Epigenetic Regulation of XIST and X-chromosome silencing in hiPSCs: Overcoming Barriers in Stem Cell-Based Therapies for Women’s Health

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Research Objective We study how the inactive X chromosome aberrantly reactivates in female pluripotent stem cells and develop ways to prevent it, enabling accurate modeling of female biology for research…

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Interrogation of tandem repeat variants contributing to neurodevelopmental and psychiatric traits using stem cell models

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Research Objective Our project will identify molecular and cellular changes induced by specific genetic variants implicated in schizophrenia and autism spectrum disorder in stem cells, neuroprogenitor cells and neurons. Impact…

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Hearing the Silence: Genome-wide Mapping of Cell-Type-Specific Silencers in the Developing Human Brain

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Research Objective We will develop genome editing tools to identify silencers that regulate neural stem cell fate, uncovering key DNA elements that guide neurodevelopment and are disrupted in neurodevelopmental diseases…

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