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Development of ROR1 CAR-T cells to target cancer stem cells in advanced malignancies

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Autologous ROR1 CAR-T cell transduced with a lentiviral vector containing scFv (cirmtuzumab) with CD28, CD137, CD3zeta signaling domains Area of Impact ROR1 expressing cancer stem cells in solid…

Continue ReadingDevelopment of ROR1 CAR-T cells to target cancer stem cells in advanced malignancies

Curing Sickle cell Disease with CRISPR-Cas9 genome editing

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate The principal objective of this program is to bring a Cas9-based gene editing cure for sickle cell disease to the pre-IND stage of development. Area of Impact The…

Continue ReadingCuring Sickle cell Disease with CRISPR-Cas9 genome editing

Curing Sickle cell Disease with CRISPR-Cas9 genome editing

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate The principal objective of this program is to bring a Cas9-based gene editing cure for sickle cell disease to the pre-IND stage of development. Area of Impact The…

Continue ReadingCuring Sickle cell Disease with CRISPR-Cas9 genome editing

Human iPSC-derived GABAergic Progenitors for Alzheimer’s Disease Treatment

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Human iPSC-derived GABAergic interneuron progenitors. Area of Impact Alzheimer's disease and related conditions. Mechanism of Action Transplantation of human iPSC-derived GABAergic progenitors, which will develop into mature GABAergic…

Continue ReadingHuman iPSC-derived GABAergic Progenitors for Alzheimer’s Disease Treatment

An autologous somatic stem cell therapy for the treatment of osteonecrosis

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate An autologous somatic stem cell therapy for the treatment of osteonecrosis. Area of Impact Osteonecrosis is a painful, progressive disease for which there is no treatment, save replacing…

Continue ReadingAn autologous somatic stem cell therapy for the treatment of osteonecrosis

Pluripotent stem cell-derived chondrocytes for articular cartilage repair

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate We propose to develop a universal, off-the-shelf treatment for articular cartilage repair based on pluripotent stem cell (PSC)-derived chondrospheres Area of Impact The proposed therapy could treat the…

Continue ReadingPluripotent stem cell-derived chondrocytes for articular cartilage repair

Personalized Cell Therapy for Diabetes

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Preclinical studies will develop patient specific stem cell-derived islets that secrete insulin & other islet hormones for regulation of blood sugar Area of Impact Genetically matched stem cell…

Continue ReadingPersonalized Cell Therapy for Diabetes

Personalized Cell Therapy for Diabetes

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Preclinical studies will develop patient specific stem cell-derived islets that secrete insulin & other islet hormones for regulation of blood sugar Area of Impact Genetically matched stem cell…

Continue ReadingPersonalized Cell Therapy for Diabetes

Human Embryonic Stem Cell-Derived Neural Stem Cell Transplants in Amyotrophic Lateral Sclerosis

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Spinal cord injections of human embryonic stem cell (hESC)-derived allogeneic neural stem cells (heNSCs) for treatment of ALS Area of Impact Treatment of Amyotrophic Lateral Sclerosis (ALS) Mechanism…

Continue ReadingHuman Embryonic Stem Cell-Derived Neural Stem Cell Transplants in Amyotrophic Lateral Sclerosis

Stem Cell-Based iNKT Cell Therapy for Cancer

  • Post author:
  • Post published:June 13, 2025
  • Post category:

Translational Candidate Lenti/iNKT-sr39TK Modified Autologous Human CD34+ Hematopoietic Stem Cells (HSCs) Area of Impact The targeted area of impact for the candidate is cancer therapy, in particular cancers that are…

Continue ReadingStem Cell-Based iNKT Cell Therapy for Cancer
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