Research Objective We will identify SAR-CoV-2 T cell epitopes for vaccine development and specific TCRs for adoptive T cell therapy using a stem cell-based platform to generate specialized dendritic cells…
Research Objective The objective is to screen a series of aminoadamantane nitrate compounds for their ability to protect hiPSC-derived neurons from SARS-CoV-2-related damage and to block SARS-CoV-2 activity. Impact If…
Research Objective We propose to use a lung stem cell based organoid to identify a new compound for COVID-19 by screening a library of FDA approved compounds that could be…
Research Objective The objective of the proposed studies is to determine which of our excipient components are necessary for survival and neuronal differentiation of our clinical cell candidate therapy for…
Research Objective We will test a novel target to augment endogenous muscle stem cell function and restore strength systemically in sarcopenia. Impact Sarcopenia can be highly disabling and has limited…
Research Objective To test of exosomes (a tiny vesicle produced by stem cells) can be used to treat brain injuries rather than having to use the entire cell. Impact Not…
Research Objective Validating the cardiac MPS as tool to predict cardiac toxicity, including modeling drug-drug interaction of polytherapy for the treatment of SARS-CoV-2. Impact Our cardiac MPS will identify polytherapy…
Research Objective We propose to evaluate both gene addition with viral vectors and CRISPR-based gene editing of a patient's own bone marrow stem cells as a curative therapy for autosomal…
Research Objective This DISC2 tests a strategy to target survival and self-renewal in glioma stem cells (GSC), and will identify a therapeutic candidate for safety, dosing and efficacy testing. Impact…
Research Objective This proposal will develop a cell-based therapy that can restore vision in retinal degeneration associated blindness such as Stargardt disease and age-related macular degeneration. Impact Chemically induced method…
