Magdalene Seiler

Institution Name:

University of California, Irvine

Total Awards:

2

Award Value:

$8,767,987

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Awards as PI

Program Type	Institution	Grant Title	Award Value
Early Translational IV	University of California, Irvine	Restoring vision by sheet transplants of retinal progenitors and retinal pigment epithelium (RPE) derived from human embryonic stem cells (hESCs)	$3,998,948
Therapeutic Translational Research Projects	University of California, Irvine	Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models	$4,769,039
			Total: $8,767,987.00

Publications

Invest Ophthalmol Vis Sci 2017 Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model. (PubMed: 28129425)
Stem Cells Int 2017 Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. (PubMed: 28928775)
Stem Cell Investig 2017 hESC-derived photoreceptors survive and integrate better in immunodeficient retina. (PubMed: 28920063)
Invest Ophthalmol Vis Sci 2018 Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. (PubMed: 29847666)
Exp Eye Res 2018 Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration. (PubMed: 29782826)
J Neurosci 2018 Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. (PubMed: 30396913)
Invest Ophthalmol Vis Sci 2020 Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction. (PubMed: 32945842)