Jeanne Loring
Institution Name:
Scripps Research Institute
Total Awards:
8
Award Value:
$17,218,315
Awards as PI
Awards as Co-PI
| Early Translational III | Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells |
Publications
- Cell Stem Cell 2010 Friedreich's ataxia induced pluripotent stem cells model intergenerational GAATTC triplet repeat instability. (PubMed: 21040903)
- Genome Res 2010 Dynamic changes in the human methylome during differentiation. (PubMed: 20133333)
- Cell Stem Cell 2011 Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. (PubMed: 21211785)
- Cell Stem Cell 2012 Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. (PubMed: 22560082)
- Nat Biotechnol 2012 Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. (PubMed: 22820318)
- EMBO Rep 2012 Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells? (PubMed: 22986548)
- Nat Cell Biol 2012 The functions of microRNAs in pluripotency and reprogramming. (PubMed: 23131918)
- Nat Methods 2012 Conversion of human fibroblasts to angioblast-like progenitor cells. (PubMed: 23202434)
- J Invest Dermatol 2013 Melanocytes derived from transgene-free human induced pluripotent stem cells. (PubMed: 23514962)
- Nat Methods 2010 Restricted ethnic diversity in human embryonic stem cell lines. (PubMed: 20038950)
- Cell Stem Cell 2010 A call to standardize teratoma assays used to define human pluripotent cell lines. (PubMed: 20452314)
- Biochem Biophys Res Commun 2010 Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system. (PubMed: 20117095)
- PLoS One 2011 Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. (PubMed: 21249129)
- Cell Stem Cell 2011 A Call for Standardized Naming and Reporting of Human ESC and iPSC Lines. (PubMed: 21474098)
- PLoS One 2011 Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State. (PubMed: 21886766)
- PLoS One 2012 Highly parallel genome-wide expression analysis of single mammalian cells. (PubMed: 22347404)
- Stem Cell Reports 2014 Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. (PubMed: 24936469)
- Nat Commun 2014 Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. (PubMed: 25034944)
- Curr Protoc Stem Cell Biol 2013 Intraspinal transplantation of mouse and human neural precursor cells. (PubMed: 24510791)
- Brain 2017 Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. (PubMed: 28137726)
- Bioessays 2016 The tumorigenic potential of pluripotent stem cells: What can we do to minimize it? (PubMed: 27417126)
- Development 2015 Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. (PubMed: 26483210)
- Stem Cells 2017 New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. (PubMed: 28009074)
- Stem Cells 2017 Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival. (PubMed: 27888558)
- Stem Cell Reports 2017 iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. (PubMed: 28392216)
- Proc Natl Acad Sci U S A 2009 Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. (PubMed: 19633196)
- Development 2013 BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a DeltaNp63+ cytotrophoblast stem cell state. (PubMed: 24004950)
- Methods Mol Biol 2015 Generation of Induced Pluripotent Stem Cells from Mammalian Endangered Species. (PubMed: 26621593)
- Nat Commun 2016 Whole-genome mutational burden analysis of three pluripotency induction methods. (PubMed: 26892726)
- Zoo Biol 2016 Rewinding the process of mammalian extinction. (PubMed: 27142508)
- Sci Rep 2015 Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells. (PubMed: 26304831)
- Elife 2015 A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. (PubMed: 26102527)
- Epigenomics 2015 DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights. (PubMed: 26067621)
- Genome Res 2015 Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells. (PubMed: 26055160)
- Expert Opin Biol Ther 2015 The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine. (PubMed: 25736263)
- PLoS One 2015 Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. (PubMed: 25714340)
- Stem Cells Transl Med 2015 Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. (PubMed: 25650438)
- Mov Disord 2015 Stem cell reprogramming: basic implications and future perspective for movement disorders. (PubMed: 25546831)
- Proc Natl Acad Sci U S A 2015 HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. (PubMed: 25535382)
- Nature 2014 Network biology: A compass for stem-cell differentiation. (PubMed: 25254472)
- Expert Rev Neurother 2014 Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. (PubMed: 25245576)
- Genomics 2014 Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells. (PubMed: 25179373)
- Ann Neurol 2014 Epigenetic therapy for Friedreich ataxia. (PubMed: 25159818)
- Stem Cell Res Ther 2014 Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. (PubMed: 25022790)
- Circ Res 2014 Epigenetic regulation of pluripotency and differentiation. (PubMed: 24989490)
- Science 2014 Research capacity. Enabling the genomic revolution in Africa. (PubMed: 24948725)
- Tissue Eng Part A 2014 A global assessment of stem cell engineering. (PubMed: 24428577)
- J Biol Chem 2014 Genomic instability in pluripotent stem cells: implications for clinical applications. (PubMed: 24362040)
- Cell Res 2014 Protein post-translational modifications and regulation of pluripotency in human stem cells. (PubMed: 24217768)
- J Cell Sci 2013 Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. (PubMed: 23813959)
- 2008 Assessment of human pluripotent stem cells with PluriTest (PubMed: 23658970)
- Trends Mol Med 2012 Ethnically diverse pluripotent stem cells for drug development. (PubMed: 23142148)
- PLoS One 2011 Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. (PubMed: 21857983)
- Methods Mol Biol 2011 Basic approaches to gene expression analysis of stem cells by microarrays. (PubMed: 21822882)
- Methods Mol Biol 2011 FISH analysis of human pluripotent stem cells. (PubMed: 21822876)
- J Stem Cells 2010 Hyaluronan is required for generation of hematopoietic cells during differentiation of human embryonic stem cells. (PubMed: 20861924)
- Am J Bioeth 2010 Growth of an industry: how U.S. scientists and clinicians have enabled stem cell tourism. (PubMed: 20461650)
- Am J Bioeth 2010 A modest proposal in response to Rhodes and Schiano. (PubMed: 20131166)
- Neuro Oncol 2010 A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells. (PubMed: 20156807)
- J Cell Biochem 2010 DNA methylation in embryonic stem cells. (PubMed: 19899110)
- PLoS One 2016 Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis. (PubMed: 27310015)
- Stem Cells Dev 2018 Autologous Induced Pluripotent Stem Cell-Derived Neurons to Treat Parkinson's Disease. (PubMed: 29790422)
Videos
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