Douglas Wallace
Institution Name:
University of California, Irvine
Total Awards:
1
Award Value:
$1,790,133
Awards as PI
| Program Type | Institution | Grant Title | Award Value |
|---|---|---|---|
| Comprehensive Grant | University of California, Irvine | The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning | $1,790,133 |
Total: $1,790,133.00 |
Publications
- JACC Cardiovasc Imaging 2011 Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis. (PubMed: 21232697)
- Science 2008 A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. (PubMed: 18276892)
- Mitochondrion 2010 Energetics, epigenetics, mitochondrial genetics. (PubMed: 19796712)
- Lab Chip 2010 Assessment of mitochondrial membrane potential using an on-chip microelectrode in a microfluidic device. (PubMed: 20383402)
- Proc Natl Acad Sci U S A 2010 Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man. (PubMed: 20445102)
- Neurobiol Aging 2010 Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. (PubMed: 20538375)
- Environ Mol Mutagen 2010 Mitochondrial DNA mutations in disease and aging. (PubMed: 20544884)
- Biol Chem 2010 Multiplex analysis of mitochondrial DNA pathogenic and polymorphic sequence variants. (PubMed: 20707610)
- Eur J Hum Genet 2011 Mitochondrial cardiomyopathies: how to identify candidate pathogenic mutations by mitochondrial DNA sequencing, MITOMASTER and phylogeny. (PubMed: 20978534)
- Annu Rev Pathol 2010 Mitochondrial energetics and therapeutics. (PubMed: 20078222)
- J Alzheimers Dis 2010 Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. (PubMed: 20463402)
- Genes Dev 2009 The pathophysiology of mitochondrial disease as modeled in the mouse. (PubMed: 19651984)
- Genes Dev 2012 mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination. (PubMed: 22345519)
- Cell 2012 Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition. (PubMed: 23063123)