Awards as PI
| Award Value | ||
|---|---|---|
| Early Translational II | Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy | $3,103,041 |
| New Faculty II | Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells | $3,065,572 |
| SEED Grant | Derivation and Characterization of Cancer Stem Cells from Human ES Cells | $616,305 |
| Alpha Stem Cell Clinics | Alpha Stem Cell Clinic for the Development of Regenerative Therapies | $7,999,137 |
Total: $14,784,055.00 |
Awards as Co-PI
| Disease Team Research I | Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) |
| Disease Team Therapy Development III | Therapeutic Eradication of Cancer Stem Cells |
Publications
- Proc Natl Acad Sci U S A 2009 Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. (PubMed: 19237556)
- Nature 2009 Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. (PubMed: 19169242)
- J Clin Oncol 2008 Chronic myeloid leukemia stem cells. (PubMed: 18539972)
- Hematology Am Soc Hematol Educ Program 2008 Chronic myeloid leukemia stem cells. (PubMed: 19074122)
- Cancer Cell 2008 Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. (PubMed: 18394555)
- J Clin Invest 2010 Chronic myeloid leukemia: mechanisms of blastic transformation. (PubMed: 20592475)
- Proc Natl Acad Sci U S A 2008 BCR-ABL-transformed GMP as myeloid leukemic stem cells. (PubMed: 19004799)
- Proc Natl Acad Sci U S A 2012 ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. (PubMed: 23275297)
- Cancer Lett 2012 Selective elimination of leukemia stem cells: Hitting a moving target. (PubMed: 22906415)
- Curr Hematol Malig Rep 2012 Chronic myeloid leukemia stem cell biology. (PubMed: 22467334)
- PLoS One 2012 NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. (PubMed: 22768113)
- Cancer Cell 2012 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (PubMed: 22897851)
- Clin Cancer Res 2010 Cancer stem cells and self-renewal. (PubMed: 20530701)
- Leuk Lymphoma 2012 Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. (PubMed: 23121619)
- Cell 2009 CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. (PubMed: 19632178)
- Cell Stem Cell 2009 The MLLgnant consequences of reverting to an embryonic transcriptional program. (PubMed: 19200795)
- PLoS One 2013 Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. (PubMed: 23527012)
- Cancer Discov 2013 TYK2-STAT1-BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia. (PubMed: 23471820)
- Cell Stem Cell 2013 A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. (PubMed: 23333150)
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