Unraveling nuclear Tau functions using age-equivalent human induced neurons from healthy aging donors and tauopathy patients
Grant Award Details
Grant Type:
Grant Number:
DISC0-17507
Investigator(s):
Award Value:
$2,137,778
Status:
Pre-Active
Grant Application Details
Application Title:
Unraveling nuclear Tau functions using age-equivalent human induced neurons from healthy aging donors and tauopathy patients
Public Abstract:
Research Objective
This project investigates how normal tau protein protects aging neurons. We'll use aging human neurons to understand how tau helps repairing DNA and why this protection fails disease.
Impact
This research would address a key bottleneck in understanding tauopathies by revealing nuclear Tau's role in DNA repair using physiologically authentic aging neurons that current models cannot provide
This project investigates how normal tau protein protects aging neurons. We'll use aging human neurons to understand how tau helps repairing DNA and why this protection fails disease.
Impact
This research would address a key bottleneck in understanding tauopathies by revealing nuclear Tau's role in DNA repair using physiologically authentic aging neurons that current models cannot provide
