Name:
Institution:
Type:
PI
Grant Award Details
San Jose State University Stem Cell Internships for Laboratory-based Learning (SJSU SCILL)
Grant Type:
Grant Number:
TB1-01195
Project Objective:
- To implement a stem cell training regimen within a two-year M.A./M.S. Biological Sciences or a Professional Science Master of Biotechnology (MBT) degree program. To develop and implement a general education course.
Investigator:
Award Value:
$4,154,051
Status:
Closed
Grant Application Details
Application Title:
- Stem Cell Internships for Laboratory-based Learning (SCILL)
Public Abstract:
A Consortium for Stem Cell Internships in Laboratory-based Learning was formed by faculty and administrators from five institutions who made a commitment to educate and train 30 students at the graduate level for careers in stem cell biology, and to increase awareness about scientific and societal issues related to stem cell biology and regenerative medicine among non-science majors. These two goals will be achieved by means of a three-year CIRM Bridges to Stem Cell Research Award. The lead University has a strong tradition of educating a diverse student population, and the Program Director heads a department that offers the extensive classroom graduate laboratory training, and operates two nationally acclaimed graduate programs. The Consortium for Stem Cell Internship program is designed to equip students with a broad-based understanding of stem cell biology through classroom instruction and seminars, and in-depth, laboratory-based expertise in a specialty area unique to each student’s professional development plan through a year-long internship. More than 60 stem cell research investigators from our consortium partner institutions are committed to educating and training graduate students of the highest caliber for careers in stem cell biology through year-long research internships and other educational-enhancing activities. Each student in the program will have diverse research internship opportunities in basic cell and molecular research at our research university partners, translational research involving stem cell product development at our corporate partner, and clinical applications of stem cell science at our non-profit institute partner. On successful completion of the curriculum and their year-long internship, these students will be awarded a master’s degree and will be well-prepared for a stem cell career. The second goal (increasing awareness about scientific and societal issues related to stem cell biology and regenerative medicine among non-science majors) will be achieved by development of curricular materials appropriate for non-science majors to be included in a general education course. Materials developed for this course will be refined for wider online distribution and made available for inclusion in other biology courses at our university and elsewhere.
Statement of Benefit to California:
A Consortium for Stem Cell Internships in Laboratory-based Learning was formed by faculty and administrators from five institutions who made a commitment to educate and train 30 students at the graduate level for careers in stem cell biology, and to increase awareness about scientific and societal issues related to stem cell biology and regenerative medicine among non-science majors. These two goals will be achieved by means of a three-year CIRM Bridges to Stem Cell Research Award. The lead University has a strong tradition of educating a diverse student population, and the Program Director heads a department that offers the extensive classroom graduate laboratory training, and operates two nationally acclaimed graduate internship programs. The Consortium for Stem Cell Internship program is designed to equip students with a broad-based understanding of stem cell biology through classroom instruction and seminars, and in-depth, laboratory-based expertise in a specialty area unique to each student’s professional development plan through a year-long internship. More than 60 stem cell research investigators from our premiere consortium partner institutions are committed to educating and training graduate students of the highest caliber for careers in stem cell biology through year-long research internships and other educational-enhancing activities. Each student in the program will have diverse research internship opportunities in basic cell and molecular research at our research university partners, translational research involving stem cell product development at our corporate partner, and clinical applications of stem cell science at our non-profit institute partner. On successful completion of the curriculum and their year-long internship, these students will be awarded a master’s degree and be well-prepared for a stem cell career. This CIRM-supported program, enthusiastically endorsed by the leaders in the stem cell arena, will ensure that California will continue to lead the nation in a providing regional stem cell workforce of the highest quality. The second goal (increasing awareness about scientific and societal issues related to stem cell biology and regenerative medicine among non-science majors) will be achieved by development of curricular materials appropriate for non-science majors to be included in a general education course. Materials developed for this course will be refined for wider online distribution and made available for inclusion in other biology courses at our university and elsewhere.
Publications
- Cancer Res (2022) Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma. (PubMed: 35294525)
- Development (2022) IL7Ralpha, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells. (PubMed: 35072209)
- Cancers (Basel) (2021) Clearing the Haze: How Does Nicotine Affect Hematopoiesis before and after Birth? (PubMed: 35008347)
- Science (2021) Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. (PubMed: 33888614)
- Nat Commun (2021) Development of selective bispecific Wnt mimetics for bone loss and repair. (PubMed: 34059688)
- Nat Biotechnol (2020) Guidelines for reporting single-cell RNA-seq experiments. (PubMed: 33188371)
- Exp Hematol (2020) Interleukin 7 receptor is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells. (PubMed: 32916215)
- Curr Top Dev Biol (2019) Chasing Mavericks: The quest for defining developmental waves of hematopoiesis. (PubMed: 30797507)
- Development (2019) The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. (PubMed: 31332039)
- Front Neurosci (2018) Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease. (PubMed: 29686602)
- NPJ Parkinsons Dis (2018) Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson's disease. (PubMed: 29928688)
- Cell (2018) Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis. (PubMed: 29856954)
- Open Forum Infect Dis (2016) Maternal Human Immunodeficiency Virus-Associated Hypergammaglobulinemia Reduces Transplacental Transfer of Immunoglobulin G to Plasmodium falciparum Antigens in Cameroonian Neonates. (PubMed: 28487863)
- Am J Trop Med Hyg (2016) Influence of Intermittent Preventive Treatment on Antibodies to VAR2CSA in Pregnant Cameroonian Women. (PubMed: 26711513)
- Stem Cell Reports (2016) CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells. (PubMed: 26771355)
- Int J Mol Sci (2016) An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs. (PubMed: 26805822)
- Cell (2016) Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. (PubMed: 27419872)
- Blood (2016) Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. (PubMed: 27207787)
- PLoS One (2016) Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice. (PubMed: 26910562)
- Malar J (2015) Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study. (PubMed: 26626275)
- Regen Med (2015) Bilayered vascular graft derived from human induced pluripotent stem cells with biomimetic structure and function. (PubMed: 26440211)
- Stem Cell Reports (2015) Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells. (PubMed: 26489895)
- Proc Natl Acad Sci U S A (2015) Temporal and spatial variation of the human microbiota during pregnancy. (PubMed: 26283357)
- PLoS One (2014) The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site. (PubMed: 24505415)
- Regen Med (2014) Human embryonic stem cell derived-mesenchymal stem cells: an alternative mesenchymal stem cell source for regenerative medicine therapy. (PubMed: 25159063)
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