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PI
Research Objective
The objective is to screen a series of aminoadamantane nitrate compounds for their ability to protect hiPSC-derived neurons from SARS-CoV-2-related damage and to block SARS-CoV-2 activity.
Impact
If successful, our screen would identify a drug candidate for further development that would protect neurons from SARS-CoV-2-related damage and also inhibit SARS-CoV-2 activity.
Major Proposed Activities
Finding a drug that positively affected the course of COVID-19 infections by protecting the nervous system AND limiting viral infectivity or virulence would have tremendous benefit for all Californians as well as everyone in the world.