Grant Award Details
To test whether human hematopoietic stem cells can be reprogrammed with Spi1 to produce human red blood cells for transplantation, ultimately as a universal source
Grant Application Details
- Reprogramming human stem cells for blood cell generation
To create a universal donor blood cell line that can be used to produce human red blood cells for transplantation.
Successful completion of this work would create a safe, unrestricted source of universal donor human blood cells that could be used to improve healthcare and save lives throughout the world.
Major Proposed Activities
- Aim 1: Development of a human donor blood cell line by introduction of the appropriate signals into stem cells
- Aim 2: Induce the human donor blood cell lines to produce red blood cells
Because this research will lead to the development of methods to address the critical shortage of universal donor blood for transfusions, the State of California and its citizens will directly benefit. California-based military personnel stationed elsewhere will also benefit from this resource. Importantly, in emergency situations, it will not be necessary to obtain blood test results to identify the recipient's blood type, thus expediting access to treatment and improving patient outcomes.