Grant Award Details

Reprogramming human stem cells for blood cell generation
Grant Number: 
DISC1-10074
Project Objective: 
  •      

    To test whether human hematopoietic stem cells can be reprogrammed with Spi1 to produce human red blood cells for transplantation, ultimately as a universal source

Investigator: 
Disease Focus: 
Blood Disorders
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$210,060
Status: 
Closed

Progress Reports

Reporting Period: 
Year 1

Grant Application Details

Application Title: 
  • Reprogramming human stem cells for blood cell generation
Public Abstract: 

Research Objective

To create a universal donor blood cell line that can be used to produce human red blood cells for transplantation.

Impact

Successful completion of this work would create a safe, unrestricted source of universal donor human blood cells that could be used to improve healthcare and save lives throughout the world.

Major Proposed Activities

  • Aim 1: Development of a human donor blood cell line by introduction of the appropriate signals into stem cells
  • Aim 2: Induce the human donor blood cell lines to produce red blood cells
Statement of Benefit to California: 

Because this research will lead to the development of methods to address the critical shortage of universal donor blood for transfusions, the State of California and its citizens will directly benefit. California-based military personnel stationed elsewhere will also benefit from this resource. Importantly, in emergency situations, it will not be necessary to obtain blood test results to identify the recipient's blood type, thus expediting access to treatment and improving patient outcomes.