Grant Award Details
Determining a novel metabolic labeling method for tracking stem cells to irradiated salivary glands using PET
Grant Application Details
- Novel metabolic labeling method for tracking stem cells to irradiated salivary glands using PET
This project aims to develop a sensitive and non-invasive method for tracking stem cells in clinical trial, without the need for genetically engineered reporters or long-lived radioisotopes.
The ability to see follow stem cells over time, as they engraft, will make it possible to predict response to stem cell therapy and understand why treatments fail, when they do.
Major Proposed Activities
- Synthesis and in vitro evaluation of a PET probe for tracking metabolically labeled stem cells
- Cell tracking of metabolically labeled human salivary stem cells to monitor tissue regeneration in a mouse model of radiation-induced xerostomia
Regenerative cell-based therapies have shown promising results for a variety of diseases, including radiation-therapy-induced xerostomia, yet practical methods for tracking transplanted cells are still lacking. This project will develop a new method for labeling sensitive stem cells without the need for genetic engineering or long-lived radionuclides. This new tool will benefit Californians by accelerating progress toward cures in ongoing CIRM-sponsored trials of stem cell therapies.