Grant Award Details

Modulation of oral epithelium stem cells by RSpo1 for the prevention and treatment of oral mucositis
Grant Number: 
DISC2-13232
Project Objective: 
  • To assess the potential of locally administered RSpo1 as a mouthwash for the prevention and treatment of oral mucositis (OM).
Investigator: 
Type: 
PI
Disease Focus: 
Other
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$942,050
Status: 
Active

Grant Application Details

Application Title: 
  • Modulation of oral epithelium stem cells by RSpo1 for the prevention and treatment of oral mucositis
Public Abstract: 

Research Objective

Locally delivered formulation of RSpo1 protein as an activator of Lgr5+ epithelial stem cells in chemotherapy- or radiation therapy-induced oral mucositis

Impact

Oral mucositis

Major Proposed Activities

  • RSpo1 formulation design and selection for optimal oral delivery
  • Activation of Wnt pathway by formulated RSpo1 in-vitro
  • Production of RSpo1 protein
  • Oral stem cell expansion by RSpo1 to protect and restore chemotherapy and radiation induced oral mucosa damage
Statement of Benefit to California: 

The proposed research will provide a new therapy for the prevention and treatment of oral mucositis - a common complication of chemotherapy and radiation therapy for cancer patients in California, the US, and globally. If successful, the product development program will also enable growth of the company which will bring more jobs and opportunities for California citizens, as the company is based here.