Grant Award Details
To test the effect of iPS-interneuron transplantation for behavioral recovery and cellular tissue repair after stroke.
Grant Application Details
- iPS-Interneuron Transplantation for Neural Repair after Stroke
To determine if transplantation of iPS-interneurons cells (iPS-3i cells) enhances functional recovery in stroke.
Successful completion of the proposed studies will develop a brain repair therapy for stroke, an unmet clinical need with significant impact on society.
Major Proposed Activities
- To determine the recovery effect of transplantation of iPS-3i cells in the mouse at subacute (7 days after stroke) and chronic (21 days) points, using measures that mimic human functional recovery.
- To determine the integration and circuit properties of transplanted iPS-3i cells in stroke at subacute and chronic time points using anatomical and optogenetic circuit mapping.
Stroke is the leading cause of adult disability. There is no medical therapy that promotes recovery in this disease. This research will test the effect of a new cellular transplant strategy to promote recovery in stroke, using induced pluripotent stem cells that have been differentiated into interneurons. These cells have markedly improved survival, migration and engraftment than previous stem cell approaches in stroke, and induce a form of plasticity that mimics the limited recovery in stroke.