IFN-γ suppresses AT2 cell regeneration to promote lung fibrosis

Research Objective

We will determine how viral infections alter lung progenitor cells thereby impairing their ability to regenerate the lungs and in turn promoting lung fibrosis.

Impact

We will define mechanisms promoting fibrosis after viral infection. Our work will also provide information on the pathobiology of other types of lung fibrosis, such as idiopathic pulmonary fibrosis.