Grant Award Details

Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2
Grant Number: 
DISC2COVID19-11941
Project Objective: 
  • To identify a catalog of peptides from Spike protein that bind to human HLA Class I molecules and stimulate CD8+ T cell responses, as the basis for novel cell-based vaccine development
Investigator: 
Institution: 
Type: 
PI
Disease Focus: 
COVID-19
Infectious Disease
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$249,999
Status: 
Active

Grant Application Details

Application Title: 
  • Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2
Public Abstract: 

Research Objective

A vaccine to help prevent COVID-19

Impact

There is a clear need for a vaccine to prevent the spread of the COVID-19 coronavirus that is effective, can be rapidly produced and can be scaled for worldwide demand.

Major Proposed Activities

  • Identify structural regions of SARS-Cov-2 that can inhibit viral entry
  • Identify potential regions that can induce CD8+ T cell responses
  • Confirm which regions produce peptides that bind to human HLA Class I molecules
  • Confirm which peptides induce antibodies inhibit viral entry using hematopoietic and bronchioalveolar stem cells
  • Identify which peptides induce CD8+ T cells that lyse cells containing Spike protein from SARS-CoV-2
Statement of Benefit to California: 

This research will result in a vaccine candidate that can be made part of an overall vaccine composition that will protect California citizens from contracting COVID-19, allowing its people to interact freely and resume normal activities.