Grant Award Details
- To identify a catalog of peptides from Spike protein that bind to human HLA Class I molecules and stimulate CD8+ T cell responses, as the basis for novel cell-based vaccine development
Grant Application Details
- Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2
A vaccine to help prevent COVID-19
There is a clear need for a vaccine to prevent the spread of the COVID-19 coronavirus that is effective, can be rapidly produced and can be scaled for worldwide demand.
Major Proposed Activities
- Identify structural regions of SARS-Cov-2 that can inhibit viral entry
- Identify potential regions that can induce CD8+ T cell responses
- Confirm which regions produce peptides that bind to human HLA Class I molecules
- Confirm which peptides induce antibodies inhibit viral entry using hematopoietic and bronchioalveolar stem cells
- Identify which peptides induce CD8+ T cells that lyse cells containing Spike protein from SARS-CoV-2
This research will result in a vaccine candidate that can be made part of an overall vaccine composition that will protect California citizens from contracting COVID-19, allowing its people to interact freely and resume normal activities.