Grant Award Details
To engineer hypo-immunogeneic cardiac patches that can assist left ventricle (LV) function after myocardial infarction without causing an immune response after allogeneic transplantation.
Grant Application Details
- Hypo-immunogenic cardiac patches for myocardial regeneration
To engineer a cardiac patch to restore function after a heart attack while avoiding an immune response (“hypo-immunogeneic” CP) when transplanted into a genetically distinct (“allogenic”) individual.
By making hypo-immunogeneic CPs and functional cardiac cells (induced pluripotent stem, “iPS” cells) available to commercial/research entities, our study can fuel the transformation of healthcare.
Major Proposed Activities
- To generate human cardiac patches using human hypo-immunogeneic iPS cell-derived cardiomyocytes and endothelial cells and perform optical mapping of the epicardial surface after transplantation.
- To study the survival of hypo-immunogeneic cardiac patches after myocardial infarction as well as their immunological acceptance and integration.
Cardiac patches with hypo-immunogeneic iPS cells have potential to restore function and prevent immune rejection, eliminating costly complications of systemic immunosuppression after pluripotent stem cell transplantation. Besides its enormous potential to improve the health of California residents, our breakthrough would also inevitably lead to licensing opportunities as well as FDA-approved cell regeneration therapy, which would generate significant future revenues for the State of California.