Grant Award Details

Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.
Grant Number: 
DISC2-12169
Investigator: 
Disease Focus: 
Neurological Disorders
Stroke
Human Stem Cell Use: 
iPS Cell
Award Value: 
$250,000
Status: 
Pre-Active

Grant Application Details

Application Title: 
  • Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia.
Public Abstract: 

Research Objective

This grant proposes development of a stem cell based therapy that is derived from human induced pluripotent stem cells. These cells are in the form of a brain support cell, an astrocyte.

Impact

The cell candidate will treat vascular dementia, the second leading cause of dementia, and stroke by overcoming a bottleneck in the ability to make large quantities of the cells for clinical use.

Major Proposed Activities

  • In vivo tumorigenic studies.
  • Development and optimization of potency assays
  • Qualification and stability of cell delivery system.
Statement of Benefit to California: 

This research will develop a therapy for a disease with no treatment, vascular dementia, that is common and devastating in its consequences. The intellectual property for this therapy is held by a State of California public university (UCLA) and commercialization will directly benefit the State of California.