Hearing the Silence: Genome-wide Mapping of Cell-Type-Specific Silencers in the Developing Human Brain
Grant Award Details
Grant Type:
Grant Number:
DISC0-17515
Investigator(s):
Award Value:
$4,244,432
Status:
Pre-Active
Grant Application Details
Application Title:
Hearing the Silence: Genome-wide Mapping of Cell-Type-Specific Silencers in the Developing Human Brain
Public Abstract:
Research Objective
We will develop genome editing tools to identify silencers that regulate neural stem cell fate, uncovering key DNA elements that guide neurodevelopment and are disrupted in neurodevelopmental diseases
Impact
The developed technology will functionally resolve the noncoding genome at unprecedented scale. The identified silencers will reveal the repressive genome architecture that governs brain development.
We will develop genome editing tools to identify silencers that regulate neural stem cell fate, uncovering key DNA elements that guide neurodevelopment and are disrupted in neurodevelopmental diseases
Impact
The developed technology will functionally resolve the noncoding genome at unprecedented scale. The identified silencers will reveal the repressive genome architecture that governs brain development.
