Genetic and Epigenetic Regulation of XIST and X-chromosome silencing in hiPSCs: Overcoming Barriers in Stem Cell-Based Therapies for Women’s Health
Grant Award Details
Grant Type:
Grant Number:
DISC0-17635
Investigator(s):
Award Value:
$2,358,742
Status:
Pre-Active
Grant Application Details
Application Title:
Genetic and Epigenetic Regulation of XIST and X-chromosome silencing in hiPSCs: Overcoming Barriers in Stem Cell-Based Therapies for Women’s Health
Public Abstract:
Research Objective
We study how the inactive X chromosome aberrantly reactivates in female pluripotent stem cells and develop ways to prevent it, enabling accurate modeling of female biology for research and therapies.
Impact
The use of female pluripotent stem cells in disease modeling, drug discovery, and regenerative therapies is currently limited by the aberrant reactivation of the inactive X chromosome in these cells.
We study how the inactive X chromosome aberrantly reactivates in female pluripotent stem cells and develop ways to prevent it, enabling accurate modeling of female biology for research and therapies.
Impact
The use of female pluripotent stem cells in disease modeling, drug discovery, and regenerative therapies is currently limited by the aberrant reactivation of the inactive X chromosome in these cells.
