Grant Award Details

Embryonic Stem Cells for Corneal Endothelial Degeneration
Grant Number: 
Project Objective: 
  • To test the hypothesis that embryonic stem cell-derived HCECs can repair the cornea in a rabbit model of corneal endothelial cell dysfunction.

Disease Focus: 
Vision Loss
Human Stem Cell Use: 
Embryonic Stem Cell
iPS Cell
Award Value: 

Progress Reports

Reporting Period: 
Year 1

Grant Application Details

Application Title: 
  • Embryonic Stem Cells for Corneal Endothelial Degeneration
Public Abstract: 

Research Objective

The proposed studies will determine the optimal approaches to differentiate and transplant stem cell-derived corneal endothelial cells.


These data will provide foundational proof-of-concept data that will allow the rapid advance of a cell therapy towards clinical application.

Major Proposed Activities

  • Determine optimal conditions to generate human corneal endothelial cells from human stem cells, assaying both cellular and functional markers.
  • Test efficacy in a rabbit model that closely mimics human injury or degeneration, examining disease-relevant functional assays.
Statement of Benefit to California: 

1. Employing California's citizens in the research funded through CIRM and thereafter as this project advances.
2. Developing a first-in-class treatment for California's citizens with corneal diseases affecting their vision.