Grant Award Details
To test the hypothesis that embryonic stem cell-derived HCECs can repair the cornea in a rabbit model of corneal endothelial cell dysfunction.
Grant Application Details
- Embryonic Stem Cells for Corneal Endothelial Degeneration
The proposed studies will determine the optimal approaches to differentiate and transplant stem cell-derived corneal endothelial cells.
These data will provide foundational proof-of-concept data that will allow the rapid advance of a cell therapy towards clinical application.
Major Proposed Activities
- Determine optimal conditions to generate human corneal endothelial cells from human stem cells, assaying both cellular and functional markers.
- Test efficacy in a rabbit model that closely mimics human injury or degeneration, examining disease-relevant functional assays.
1. Employing California's citizens in the research funded through CIRM and thereafter as this project advances.
2. Developing a first-in-class treatment for California's citizens with corneal diseases affecting their vision.