Grant Award Details
- The overall goal of the project is to understand endothelial cell (EC) differentiation to provide a basis for the in vitro derivation of distinct EC subtypes.
Progress Reports
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Grant Application Details
- Directed Differentiation of Specialized Endothelial Cells
Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes.
Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes for treating these patients.
Publications
- Stem Cells Dev (2018) Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. (PubMed: 29320922)
- Biofabrication (2017) Leaf-inspired microcontact printing vascular patterns. (PubMed: 28488588)
- Stem Cells Dev (2017) Development of Mural Cells: From In Vivo Understanding to In Vitro Recapitulation. (PubMed: 28462621)
- Cell Commun Signal (2017) Metabolic shift in density-dependent stem cell differentiation. (PubMed: 29052507)
- PLoS One (2016) Multifactorial Optimizations for Directing Endothelial Fate from Stem Cells. (PubMed: 27907001)
- Stem Cells Cloning (2014) Specialized mouse embryonic stem cells for studying vascular development. (PubMed: 25328412)