Defining Neurovascular Metabolism in Neurodevelopmental and Neuropsychiatric Disorders
Grant Award Details
Grant Type:
Grant Number:
DISC4-16337
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Cell Line Generation:
Award Value:
$10,330,000
Status:
Pre-Active
Grant Application Details
Application Title:
Defining Neurovascular Metabolism in Neurodevelopmental and Neuropsychiatric Disorders
Public Abstract:
Research Objective
Neuropsychiatric disorders correlate to impaired metabolism, though understudied. We will describe how metabolism impacts disorders etiology and identify new, tractable therapeutic strategies.
Impact
We will uncover metabolic drivers of neuropsychiatric disorders, resulting in new therapeutic targets including rigorously investigated dietary interventions and novel metabolic drug targets.
Neuropsychiatric disorders correlate to impaired metabolism, though understudied. We will describe how metabolism impacts disorders etiology and identify new, tractable therapeutic strategies.
Impact
We will uncover metabolic drivers of neuropsychiatric disorders, resulting in new therapeutic targets including rigorously investigated dietary interventions and novel metabolic drug targets.
Statement of Benefit to California:
Strong data suggests metabolism is involved in the emergence of neuropsychiatric disorders, impacting a large fraction of Californians. Metabolism as studied in this project opens an entirely new horizon for drug development; members of our team have already brought metabolism targeting drugs to clinic for other indications and these data may also suggest ways in which diet can be therapeutically leveraged. These new strategies will positively impact patient and family well being.
