CSUN CIRM COMPASS Training Program (N-COMPASS)

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Grant Award Details

Grant Number:
EDUC5-13665
Award Value:
$2,680,805
Status:
Active

Progress Reports

Reporting Period:
Year 1
Reporting Period:
Year 2

Grant Application Details

Application Title:

CSUN CIRM COMPASS Training Program (N-COMPASS)

Public Abstract:
The main focus of the CSUN CIRM COMPASS Training Program (N-COMPASS) is heavily weighted on goal-oriented academic and practical laboratory training experiences in stem cell biology and stem cell-based patient therapies. Our program is integrated with educational, ethical, and guidance features for culturally diverse early-career undergraduate students. Our internship-host institutions provide mentors who are world leaders in fundamental stem cell research and therapeutic translational applications. We have both industry and academic partners that will provide hands-on training in embryonic and adult or cell type-specific stem cell biology, gene therapy, and targeted research in human disease, spanning the basic to translational investigative spectrum. Our partnerships achieve all of the major COMPASS Program objectives including 1) training laboratory personnel in current stem cell research techniques, policy, and ethics, 2) introducing community outreach, patient advocacy, and career counseling for future stem cell-based therapies, and 3) facilitating the entry of an ethnically and culturally diverse student population into the emerging world of stem cell biology and regenerative medicine. Our training program will provide CIRM trainees with opportunities to study the latest advances in stem cell biology, present their own work in settings in which they can obtain constructive feedback, interact with their peers in formal and informal forums, to meet leaders in the field, interact with patients, and to develop their career potential through advisement and mentoring. Students in COMPASS will experience three years of cohorted academic support including ten-week summer internships for two consecutive years. Host-internship mentors will undergo DEI and Critical Mentorship training prior to matching them with academically supported and prepared COMPASS trainees. The majority of intern time will be spent on laboratory research. Trainees will learn stem cell and essential analysis techniques such as microscopy, cell sorting, and good laboratory practices in the internship-host lab and affiliated cores. Their projects will be discussed and chosen in partnership with the lab mentor, who will pair trainees with more advanced senior graduate or post-doctoral students working in the area of the trainee’s project. These hands-on experiences will be supplemented by academic year participation in career counseling, community outreach, patient advocacy, and by formal and informal mentoring by home and host-institution faculty and peers. A major purpose of our inter-institutional training program is to provide an opportunity for engaged, interested, and successful trainees to gain the necessary skills and qualifications to springboard into careers in stem cell research that spans the spectrum, from basic studies to translational approaches to stem cell-based patient therapies, in academia and industry.
Statement of Benefit to California:
With substantial spending in connection with its operations, our institution has immense economic, fiscal, and social impacts far beyond the Northridge community. Our institution has an overall economic impact of nearly $1.9. Economic output generated by our institution-related spending generated nearly $677.6 million in increased wages and earnings, raising labor income across the state. Of the total labor income generated, $588.6 million landed in Los Angeles County. The additional income generated by our institution-related expenditures was primarily spent within the local economy, which, together with the increased demand for labor driven by these expenditures, resulted in a cumulative total of 11,774 jobs supported across all industries in California. Of these new jobs, 10,369 originated in Los Angeles County. In addition, our institution employees provided added value to state and local governments in increased tax revenue at a total of $122.1 million. Our trainees will have tangible health and economic impact on California, its academic institutions, its biotechnology, pharmaceutical, and stem cell companies, and the rest of the nation as California and its people move forward with personalized medicine during the 21st century. Our host institutions are economic powerhouses for Los Angeles, Southern California, and California overall. Our host institutions generated over $11 billion in economic activity and supported more than 100,000 full-time jobs throughout the state during the 2016–17 fiscal year. Our academic host institutions are renowned worldwide for the quality of faculty, students, and trainees and their dedication to the mission of research, teaching, and service. Biocom’s 2019 Economic Impact Report Databook revealed the emergence of Los Angeles County as the third hub of California’s biotech sector. Last year all life science industry sectors generated $42.5 billion in economic activity and added $23.5 billion to LA County's gross profit. There are approximately 92,000 related jobs in the region, with an average earning of $83,000. According to the report, those jobs also support almost 191,000 peripheral jobs in the region. The largest benefit to California is the benefit to our students. “The objective of the N-COMPASS Training Program is to prepare a diverse cadre of undergraduate students for careers in regenerative medicine through the creation of novel recruitment and support mechanisms that identify and foster untapped talent within populations that are historically underrepresented in the biomedical sciences, and by combining hands-on research opportunities with strategic and structured mentorship experiences to enhance the transition of students to successful careers.” The N-COMPASS training program is dedicated and ready for this new mission.

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