Grant Award Details
- The CESCG has multiple "center initiated projects" CIPs that are done by core sites, and "collaborative research projects" CRPs done by individual research labs around California. All data is supposed to funnel into a central "stem cell hub" to create a single resource of data and bioinformatics tools.
Progress Reports
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Grant Application Details
- Center of Excellence for Stem Cell Genomics
The Center of Excellence in Stem Cell Genomics will bring together investigators from seven major California research institutions to bridge two fields – genomics and pluripotent stem cell research. The projects will combine the strengths of the center team members, each of whom is a leader in one or both fields. The program directors have significant prior experience managing large-scale federally-funded genomics research programs, and have published many high impact papers on human stem cell genomics. The lead investigators for the center-initiated projects are expert in genomics, hESC and iPSC derivation and differentiation, and bioinformatics. They will be joined by leaders in stem cell biology, cancer, epigenetics and computational systems analysis. Projects 1-3 will use multi-level genomics approaches to study stem cell derivation and differentiation in heart, tumors and the nervous system, with implications for understanding disease processes in cancer, diabetes, and cardiac and mental health. Project 4 will develop novel tools for computational systems and network analysis of stem cell genome function. A state-of-the-art data management program is also proposed. This research program will lead the way toward development of the safe use of stem cells in regenerative medicine. Finally, Center resources will be made available to researchers throughout the State of California through a peer-reviewed collaborative research program.
Publications
- Proc Natl Acad Sci U S A (2017) Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. (PubMed: 29203658)
- Circ Res (2017) Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs. (PubMed: 28663367)
- Sci Data (2016) An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development. (PubMed: 27996962)
- Pac Symp Biocomput (2016) TRACING CO-REGULATORY NETWORK DYNAMICS IN NOISY, SINGLE-CELL TRANSCRIPTOME TRAJECTORIES. (PubMed: 27897008)
- Cell Rep (2016) Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. (PubMed: 27681438)
- Cancer Cell (2016) N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. (PubMed: 27050099)
- PLoS Comput Biol (2016) Pathway-Based Genomics Prediction using Generalized Elastic Net. (PubMed: 26960204)
- Pac Symp Biocomput (2016) ONE-CLASS DETECTION OF CELL STATES IN TUMOR SUBTYPES. (PubMed: 26776204)
- Mol Cell (2016) Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA. (PubMed: 27105112)
- Nat Methods (2016) Inferring causal molecular networks: empirical assessment through a community-based effort. (PubMed: 26901648)
- Cell (2016) Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. (PubMed: 27499020)
- Proc Natl Acad Sci U S A (2015) A basal stem cell signature identifies aggressive prostate cancer phenotypes. (PubMed: 26460041)
- Cell Stem Cell (2015) Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions. (PubMed: 26095048)
- Cell Syst (2015) NDEx, the Network Data Exchange. (PubMed: 26594663)
- Cell (2014) Integrated genomic characterization of papillary thyroid carcinoma. (PubMed: 25417114)