Autologous iPSC-based therapy for radiation induced bladder injury
Grant Award Details
Grant Type:
Grant Number:
DISC1-08731
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$235,836
Status:
Closed
Progress Reports
Reporting Period:
Year 2 Final Report
Grant Application Details
Application Title:
Autologous iPSC-based therapy for radiation induced bladder injury
Public Abstract:
Research Objective
To explore if iPSC-based therapy can prevent bladder damage due to radiation therapy, thereby limiting the unintended consequences of treatments for prostate, gynecologic and colorectal cancers.
Impact
This therapy impacts cancer survivors by preventing the permanent debilitating urinary symptoms due to radiation therapy. Currently there are no therapies to prevent radiation bladder damage.
Major Proposed Activities
To explore if iPSC-based therapy can prevent bladder damage due to radiation therapy, thereby limiting the unintended consequences of treatments for prostate, gynecologic and colorectal cancers.
Impact
This therapy impacts cancer survivors by preventing the permanent debilitating urinary symptoms due to radiation therapy. Currently there are no therapies to prevent radiation bladder damage.
Major Proposed Activities
- Optimize and characterize a chronic radiation cystitis rat model (6 months) using two radiation doses (25 Gy and 35 Gy) to establish time course and baseline changes in inflammatory parameters.
- Inject human iPSC-derived pSMCs into the bladder of rat model after radiation to evaluate the effect of pSMC on bladder function and scarring/fibrosis.
Statement of Benefit to California:
Pelvic cancers such as prostate, gynecologic, and colorectal cancers are often treated with radiation therapy(RT). Roughly 54,000 new cases are diagnosed annually in California. Despite RT advances, unintended chronic bladder damage cause debilitating bladder symptoms in up to 10% of patients. Therapies to ameliorate these symptoms are lacking and risky. We propose a stem-cell-based therapy. Our treatment could improve the post-cancer recovery of Californians who currently suffer needlessly.
