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Genomic instability during culturing of human embryonic stem cells

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  • Post published:June 30, 2025
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Human embryonic stem cells (hESCs) have important potential in the treatment of human disease. Because they can change into a large number of different cell types, they may be useful…

Continue ReadingGenomic instability during culturing of human embryonic stem cells

Generation and characterization of corticospinal neurons from human embryonic stem cells

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  • Post published:June 30, 2025
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A major goal of stem cell research is to generate various functional human cell types that can be used to better understand how these cells work and to use them…

Continue ReadingGeneration and characterization of corticospinal neurons from human embryonic stem cells

Enhancer-mediated gene regulation during early human embryonic development

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  • Post published:June 30, 2025
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Less than 2% of the human genome encodes protein coding genes. But many trait-specific and disease specific mutations seem to map away from such coding sequences. This paradox is partially…

Continue ReadingEnhancer-mediated gene regulation during early human embryonic development

Molecular determinants of accurate differentiation from human pluripotent stem cells

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  • Post published:June 30, 2025
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The use of human pluripotent stem cells for cell-based therapeutics is predicated on the ability to convert these cells into functional equivalents of those lost in disease or injury. However,…

Continue ReadingMolecular determinants of accurate differentiation from human pluripotent stem cells

Etsrp/ER71 mediated stem cell differentiation into vascular lineage

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  • Post published:June 30, 2025
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Human embryonic stem cells (hESC) have the potential to differentiate into all of the cell types that make up the body. Therefore, hESCs are promising tools for the treatment of…

Continue ReadingEtsrp/ER71 mediated stem cell differentiation into vascular lineage

Ubiquitin-dependent control of hESC self-renewal and expansion

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  • Post published:June 30, 2025
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Human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) provide an invaluable resource for regenerative medicine and disease modeling. To be able to use these cells in the…

Continue ReadingUbiquitin-dependent control of hESC self-renewal and expansion

Forming the Hematopoietic Niche from Human Pluripotent Stem Cells

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  • Post published:June 30, 2025
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The clinical potential of pluripotent stem cells for use in regenerative medicine will be realized only when the process by which tissues are generated from these cells is significantly more…

Continue ReadingForming the Hematopoietic Niche from Human Pluripotent Stem Cells

Biological relevance of microRNAs in hESC differentiation to endocrine pancreas

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  • Post published:June 30, 2025
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There remains an urgent and critical need for a cell-based cure of diabetes, one of the most costly diseases in California. Islet transplantation with persistent immune suppression has shown promise…

Continue ReadingBiological relevance of microRNAs in hESC differentiation to endocrine pancreas

Homologous recombination in human pluripotent stem cells using adeno-associated virus.

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  • Post published:June 30, 2025
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Since their discovery in 1998, human embryonic stem cells (hESCs) have been considered to hold great potential for the treatment of many currently incurable diseases. Possibly the most exciting application…

Continue ReadingHomologous recombination in human pluripotent stem cells using adeno-associated virus.

Cellular tools to study brain diseases affecting synaptic transmission

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  • Post published:June 30, 2025
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There is a group of brain diseases that are caused by functional abnormalities. The brains of patients afflicted with these diseases which include autism spectrum disorders, schizophrenia, depression, and mania…

Continue ReadingCellular tools to study brain diseases affecting synaptic transmission
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