Placental Stem Cells for the In Utero Treatment of Spina Bifida
Myelomeningocele – also known as spina bifida – is a devastating and costly defect that causes lifelong paralysis as well as bowel and bladder incontinence in newborns. It is one…
Alpha Stem Cell Clinic for the Development of Regenerative Therapies
The proposed alpha clinic will bring together an outstanding team of physician-scientists with substantial clinical trials experience including stem cell and other cellular treatments of blood diseases and others. This…
UCLA-UCI Alpha Stem Cell Clinic (ASCC) Consortium
Two world renowned research universities with their regional partners will join forces to create the CIRM Alpha Stem Cell Clinic (ASCC) Consortium. We are uniquely qualified by our respective institutional…
Multi-modal technology for non-destructive characterization of bioengineered tissues
Stem cell technologies hold great promise for engineering replacement tissues for repairing functional loss from trauma or disease. Such therapies are particularly important for replacing bone and cartilage in the…
Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction
The intestine performs the essential function of absorbing food and water into the body. Without a functional intestine, children and adults cannot eat normal meals, and these patients depend on…
Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction
The intestine performs the essential function of absorbing food and water into the body. Without a functional intestine, children and adults cannot eat normal meals, and these patients depend on…
Multimodal platform combining optical and ultrasonic technologies for in vivo nondestructive evaluation of engineered vascular tissue constructs
Current vascular replacement materials are far from ideal, with all available biomaterials exhibiting significant clinical complications. The development of novel biocompatible decellularized vascular grafts holds great promise for functional restoration…
Site-specific gene editing in hematopoietic stem cells as an anti-HIV therapy
The overall goal of this proposal is to develop new methods and technologies to improve our ability to engineer hematopoietic stem cells. These are the adult stem cells found in…
Injectable Macroporous Matrices to Enhance Stem Cell Engraftment and Survival
Despite the great promise stem cells hold for regenerative medicine, the efficacy of stem cell-based therapies is greatly limited by poor cell engraftment and survival. To overcome this major bottleneck,…
Small molecule tools and scale-up technologies to expand human umbilical cord blood stem and progenitor cells for clinical and research use
Tens of thousands of patients need bone marrow transplants (BMT) every year, some for bone marrow (BM) cancers and some for inherited diseases such as sickle cell anemia and thalassemia,…
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