Disease Focus: Vascular Disease

Direct reprogramming towards vascular progenitors for the treatment of ischemia

Angiogenesis or the generation of new blood vessels is a critical part of the normal healing process. Newly created vessels ensure the delivery of oxygen, nutrients, and specific repair signals to injured tissues. Indeed, even though additional repair mechanisms are required, such as replenishment of tissue-specific cell types, angiogenesis contributes to the healing of a […]

A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells

Cardiovascular diseases account for an estimated $330 billion in health care costs each year, afflict 61.8 million Americans, and will account for more than 1.5 million deaths in the U.S. this year alone. A number of these diseases are characterized by either insufficient blood vessel growth or damage to the existing vessels, resulting in inadequate […]

VEGF signaling in adventitial stem cells in vascular physiology and disease

Coronary heart disease is the leading cause of death in the developed world. This disease results from atherosclerosis or fatty deposits in the vessel wall that causes blockage of coronary arteries. Blockage of these arteries cut off supplies of nutrients and oxygen to the heart muscle, causing heart attacks, heart failure or sudden death. To […]

EC regeneration in cerebrovascular ischemia: role of NO

Stroke is the third leading cause of death and the leading cause of disability in this country, affecting about 650,000 people in the US each year. Currently approved therapies for stroke are directed toward acutely restoring blood flow (using drugs that break up clot). A new approach is to use stem cells to regenerate portions […]

Cardiovascular Therapies: Spotlight on Stem Cell Research – Welcoming Remarks

Robert Klein, J.D. and Claire Pomeroy, M.D., M.B.A., gave the welcoming remarks for the “Spotlight on Cardiovascular Therapies,” an educational event presented at the California Institute for Regenerative Medicine Governing Board meeting on March 10, 2011 in Burlingame, CA. Klein is Chair of the CIRM Governing Board. Pomeroy is Vice Chancellor for Human Health Sciences […]

Cardiovascular Therapies: Spotlight on Stem Cell Research – Yung-Wei Chi

“Stem Cell Research: Where are we with Peripheral Arterial Disease (PAD)” On March 10, 2011, Yung-Wei Chi, D.O., spoke about a recently launched clinical trial that using a patient’s own stem cells to help prevent amputations due to peripheral arterial disease. Chi is an associate professor of medicine at the UC Davis Vascular Center. Chi […]

Cardiovascular Therapies: Spotlight on Stem Cell Research – Jeanette Owens

“Patient Advocate Speaker” On March 10, 2011, Jeanette Owens spoke about living with peripheral arterial disease and about her hopes for stem cell treatments. Owens was introduced by Claire Pomeroy, M.D., M.B.A., vice chancellor for Human Health Sciences at UC Davis and dean of the UC Davis School of Medicine. Pomeroy is also a member […]