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Epigenetics in cancer stem cell initiation and clinical outcome prediction

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Cancer is responsible for approximately 25% of all deaths in the US and other developed countries. For women, breast and lung cancers and for men, cancers of prostate and lung…

Continue ReadingEpigenetics in cancer stem cell initiation and clinical outcome prediction

Stem Cells for Immune System Regeneration to Fight Cancer

  • Post author:
  • Post published:June 9, 2025
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This proposal will define the biology of stem cell engineering to produce a cancer-fighting immune system. The immune system protects our body against most outside threats. However, it frequently fails…

Continue ReadingStem Cells for Immune System Regeneration to Fight Cancer

Stem Cells in Lung Cancer

  • Post author:
  • Post published:June 9, 2025
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Lung cancer is the most deadly cancer worldwide and accounts for more deaths than prostate cancer, breast cancer and colon cancer combined. Non small cell lung cancer (NSCLC) accounts for…

Continue ReadingStem Cells in Lung Cancer

Generation of clinical grade human iPS cells

  • Post author:
  • Post published:June 9, 2025
  • Post category:

The therapeutic use of stem cells depends on the availability of pluripotent cells that are not limited by technical, ethical or immunological considerations. The goal of this proposal is to…

Continue ReadingGeneration of clinical grade human iPS cells

Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells

  • Post author:
  • Post published:June 9, 2025
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The overall goal of the proposed studies is to utilize human gene therapy approach using human embryonic stem cells to direct our body’s defenses to specifically attack melanoma tumor cells.…

Continue ReadingGenetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells

hESC as tools to investigate the neural crest origin of Ewing’s sarcoma

  • Post author:
  • Post published:June 9, 2025
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Human embryonic stem cells (hESC) hold great promise as sources of tissue for regenerative medicine and therapeutics. In addition, their utility as tools to study the origins and biology of…

Continue ReadinghESC as tools to investigate the neural crest origin of Ewing’s sarcoma

Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)

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  • Post published:June 9, 2025
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Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites. Despite advances in surgical, radiation, pharmacologic, and gene therapies, survival with a BT…

Continue ReadingStem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)

Stem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials

  • Post author:
  • Post published:June 9, 2025
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Despite aggressive multimodal therapy and advances in imaging, surgical and radiation techniques, malignant brain tumors (high-grade gliomas) remain incurable, with survival often measured in months. Treatment failure is largely attributable…

Continue ReadingStem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials

Therapeutic Opportunities To Target Tumor Initiating Cells in Solid Tumors

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Cancer is a major cause of human death worldwide. The vast majority of cancer patients suffer from solid tumors whose growth destroys vital organs. We propose to develop novel therapeutic…

Continue ReadingTherapeutic Opportunities To Target Tumor Initiating Cells in Solid Tumors

UCLA Clinical Trial Targets Cancer Stem Cells: A Patient’s Story

  • Post author:cirmadmin
  • Post published:September 30, 2015
  • Post category:

When Frank Gonzales was diagnosed with colorectal cancer in November 2010 it was the start of a long fight against the disease. Chemotherapy helped keep the cancer in check, but…

Continue ReadingUCLA Clinical Trial Targets Cancer Stem Cells: A Patient’s Story
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