A modular automation approach to stem cell modeling to increase throughput, reproducibility and access

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This project enhances stem cell access, scalability, and collaboration. It offers characterized hPSC lines, CRISPR editing, and differentiation on automated platforms accelerating progress in biology, disease research, and regenerative medicine.…

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iPSC-derived smooth muscle cell progenitor conditioned medium for treatment of pelvic organ prolapse

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Research Objective Conditioned media from human iPSC-derived smooth muscle cell progenitors. This media exerts paracrine effect to restore damaged vaginal wall in patients with pelvic organ prolapse. Impact Pelvic organ…

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Pluripotent stem cell-derived bladder epithelial progenitors for definitive cell replacement therapy of bladder cancer

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Research Objective We will 1) identify non-invasive bladder cancer patients with (pre)cancerous urothelium by single-cell RNA-seq and 2) replace this dangerous lesion with normal hESC-derived bladder progenitors. Impact Replacement of…

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Identification and Generation of Long Term Repopulating Human Muscle Stem Cells from Human Pluripotent Stem Cells

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Research Objective We will molecularly and functionally define muscle stem cells in human muscle in development, juvenile and adult and develop strategies to generate the most regenerative muscle stem cells…

Continue ReadingIdentification and Generation of Long Term Repopulating Human Muscle Stem Cells from Human Pluripotent Stem Cells