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Viral-host interactions affecting neural differentiation of human progenitors

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  • Post published:May 20, 2025
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Human cytomegalovirus (HCMV) is the major cause of birth defects, almost all of which are neuronal in origin. Approximately 1% of newborns are infected, and of the 13% that are…

Continue ReadingViral-host interactions affecting neural differentiation of human progenitors

Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

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  • Post published:May 20, 2025
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Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases that occur in as many as 1 in 150 children in the United States. Three hallmarks of autism are dysfunctional…

Continue ReadingInvestigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

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  • Post published:May 20, 2025
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Heart disease is the number one cause of death and disability in California and in the United States. Especially devastating is Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), an inherited form of…

Continue ReadingMolecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

Cellular tools to study brain diseases affecting synaptic transmission

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  • Post published:May 20, 2025
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There is a group of brain diseases that are caused by functional abnormalities. The brains of patients afflicted with these diseases which include autism spectrum disorders, schizophrenia, depression, and mania…

Continue ReadingCellular tools to study brain diseases affecting synaptic transmission

Use of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy.

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  • Post published:May 20, 2025
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Spinal Muscular Atrophy (SMA) is one of the most common lethal genetic diseases in children. One in thirty five people carry a mutation in a gene called survival of motor…

Continue ReadingUse of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy.

Use of hiPSCs to develop lead compounds for the treatment of genetic diseases

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  • Post published:May 20, 2025
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This study will use Ataxia-Telangiectasia (A-T), an early-onset inherited neurodegenerative disease of children, as a model to study the mechanisms leading to cerebellar neurodegeneration and to develop a drug that…

Continue ReadingUse of hiPSCs to develop lead compounds for the treatment of genetic diseases

Development of small molecule screens for autism using patient-derived iPS cells

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  • Post published:May 20, 2025
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Autism Spectrum Disorders (ASDs) are a heritable group of neuro-developmental disorders characterized by language impairments, difficulties in social integrations, and the presence of stereotyped and repetitive behaviors. There are no…

Continue ReadingDevelopment of small molecule screens for autism using patient-derived iPS cells

Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders

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  • Post published:May 20, 2025
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Our research group at [REDACTED] has had a long-standing interest in understanding the cause of several disorders that result in severe, and often times fatal forms of diarrhea in children.…

Continue ReadingPluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders

Inhibitory Nerve Cell Precursors: Dosing, Safety and Efficacy

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  • Post published:May 20, 2025
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Many neurological disorders are characterized by an imbalance between excitation and inhibition. Our ultimate goal: to develop a cell-based therapy to modulate aberrant brain activity in the treatment of these…

Continue ReadingInhibitory Nerve Cell Precursors: Dosing, Safety and Efficacy

Stem Cell Therapy for Duchenne Muscular Dystrophy

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  • Post published:May 20, 2025
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Duchenne muscular dystrophy (DMD) is the most common and serious form of muscular dystrophy. One out of every 3500 boys is born with the disorder, and it is invariably fatal.…

Continue ReadingStem Cell Therapy for Duchenne Muscular Dystrophy
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