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Neuroprotection to treat Alzheimer’s: a new paradigm using human central nervous system cells

  • Post author:
  • Post published:August 30, 2025
  • Post category:

Alzheimer’s disease (AD) is an incurable disorder that affects memory, social interaction and the ability to perform everyday activities. In the USA alone, the number of AD patients aged 65…

Continue ReadingNeuroprotection to treat Alzheimer’s: a new paradigm using human central nervous system cells

Neural Stem Cell-Based Therapy For Parkinson’s Disease

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  • Post published:August 30, 2025
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Ongoing degeneration of dopaminergic (DA) neurons in the midbrain is the hallmark of Parkinson’s disease (PD), a movement disorder that manifests with tremor, bradykinesia and rigidity. One million Americans live…

Continue ReadingNeural Stem Cell-Based Therapy For Parkinson’s Disease

hESC-derived NPCs Programmed with MEF2C for Cell Transplantation in Parkinson’s Disease

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  • Post published:August 30, 2025
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We proposes to use human embryonic stem cells (hESCs) differentiated into neural progenitor/stem cells (NPCs), but modified by transiently programming the cells with the transcription factor MEF2C to drive them…

Continue ReadinghESC-derived NPCs Programmed with MEF2C for Cell Transplantation in Parkinson’s Disease

A CIRM Disease Team to Develop Allopregnanolone for Prevention and Treatment of Alzheimer’s Disease

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  • Post published:August 30, 2025
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Alzheimer’s disease (AD) is now a nation-wide epidemic and California is at the epicenter of the epidemic. One-tenth of all people in the United States diagnosed with AD live in…

Continue ReadingA CIRM Disease Team to Develop Allopregnanolone for Prevention and Treatment of Alzheimer’s Disease

Evaluation of Safety and Preliminary Efficacy of Escalating Doses of GRNOPC1 in Subacute Spinal Cord Injury

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  • Post published:August 30, 2025
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The proposed project is designed to assess the safety and preliminary activity of escalating doses of human embryonic stem cell (hESC) derived oligodendrocyte progenitor cells for treatment of spinal cord…

Continue ReadingEvaluation of Safety and Preliminary Efficacy of Escalating Doses of GRNOPC1 in Subacute Spinal Cord Injury

Use of human iPS cells to study spinal muscular atrophy

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  • Post published:August 30, 2025
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Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders that cause infant mortality. SMA is caused by loss of the Survival of Motor Neuron (SMN) protein,…

Continue ReadingUse of human iPS cells to study spinal muscular atrophy

Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo

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  • Post published:August 30, 2025
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Stem cells, including human embryonic stem cells, provide extraordinary new opportunities to model human diseases and may serve as platforms for drug screening and validation. Especially with the ever-improving effective…

Continue ReadingStudying neurotransmission of normal and diseased human ES cell-derived neurons in vivo

Viral-host interactions affecting neural differentiation of human progenitors

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  • Post published:August 30, 2025
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Human cytomegalovirus (HCMV) is the major cause of birth defects, almost all of which are neuronal in origin. Approximately 1% of newborns are infected, and of the 13% that are…

Continue ReadingViral-host interactions affecting neural differentiation of human progenitors

Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

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  • Post published:August 30, 2025
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Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases that occur in as many as 1 in 150 children in the United States. Three hallmarks of autism are dysfunctional…

Continue ReadingInvestigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

Triplet Repeat Instability in Human iPSCs

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  • Post published:August 30, 2025
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Over twenty human genetic diseases are caused by expansion of simple DNA sequences composed of repeats of three nucleotides (such as CAG, CTG, CGG and GAA) within essential genes. These…

Continue ReadingTriplet Repeat Instability in Human iPSCs
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