Research Objective We propose to discover a novel, genetically modified hematopoietic stem cell based treatment for Danon disease, a rare lysosomal storage disease that affects the heart. Impact As the…
Research Objective This proposal investigates the effects of the microenvironment on the development and maintenance of pacemaking function in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Impact Pacemaking function of…
Research Objective We developed technology to reproducibly prepare large numbers of bonafide cardiac progenitor cells from patient iPSCs. We propose the first test of these cells as a therapy for…
Research Objective This proposal will develop patient specific ‘heart-on-a-chip’ devices that will significantly impact early screening of drugs to accurately predict drug-induced proarrhythmia and toxicity. Impact Patient specific ‘heart-on-a-chip’ device…
Research Objective To develop a gene therapy product to deliver cardiac reprogramming factors into the heart for regeneration of new heart muscle. Impact The proposed candidate would regenerate heart muscle…
Research Objective To develop drugs to treat Calcific Aortic Valve Disease (CAVD), the third leading cause of adult heart disease, by screening a stem cell-based platform based on CAVD patient-derived…
California's Stem Cell Agency (CIRM) has catalyzed the growth of stem cell research by helping recruit scientists to the state. In this video, we feature Dr. Todd McDevitt, a leading biomedical…
Watch this Google Hangout to learn about recent progress in developing stem cell therapies for heart disease. Hear from stem cell clinical trial participant Fred Lesikar, stem cell experts Dr.…
Title: Lessons learned from Phase 1 trial of heart-derived stem cells as we move into Phase 2 Speaker: Eduardo Marbán, M.D., Ph.D. Founder and Chairman of Scientific Advisory Board, Capricor,…
Get the latest CIRM news, information on upcoming meetings, and funding opportunities delivered to your inbox.
