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Human Pancreatic Cancer Stem Cells: Developing a Novel Drug for Cancer Eradication

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Research Objective We will use human pancreatic cancer (PC) stem cells to show 1 inhibits proliferation, self-renewal and cell viability. This paradigm is transformational for anti-cancer drug discovery for patients.…

Continue ReadingHuman Pancreatic Cancer Stem Cells: Developing a Novel Drug for Cancer Eradication

Identification of stem cell surface markers as potential therapeutic targets for advanced prostate cancer

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Research Objective The goal of this proposal is to identify proteins found on the surface of both human prostate stem cells and cancer cells that could be used as potential…

Continue ReadingIdentification of stem cell surface markers as potential therapeutic targets for advanced prostate cancer

Genome editing for causation and reversion of MPN-associated mutations in human hematopoietic stem cells

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Research Objective Use gene editing to create tools for the study of mechanisms by which patient-observed mutations lead to myeloproliferative neoplasms. Impact Editing reagents will yield new insight into how…

Continue ReadingGenome editing for causation and reversion of MPN-associated mutations in human hematopoietic stem cells

Curing bladder cancer by replacing corrupted urothelium with differentiated hES cells

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Research Objective The goal of the proposed research is to use human embryonic stem cells to generate bladder epithelial progenitor cells that can be used to replace a cancerous bladder…

Continue ReadingCuring bladder cancer by replacing corrupted urothelium with differentiated hES cells

Purification of Human Hematopoietic Stem Cells (HSCs) for Clinical Stem Cell Transplantation

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Translational Candidate Two new monoclonal antibodies anti-CD34 and anti-CD90, and protocols to purify cancer-free and/or T cell free human HSC for clinical transplantation. Area of Impact The development of hematopoietic…

Continue ReadingPurification of Human Hematopoietic Stem Cells (HSCs) for Clinical Stem Cell Transplantation

A Rapid Clinical Digital Patient-derived Organoid to Guide Breast Cancer Treatment Decision

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Translational Candidate The digital patient organoid (DPO) assay is a microfluidic miniature organoid technology that allows high-throughput drug testing. Area of Impact Our functional DPO assay will guide personalized therapy…

Continue ReadingA Rapid Clinical Digital Patient-derived Organoid to Guide Breast Cancer Treatment Decision

GlyTR2 CAR T cell translation: safe pan-cancer killing via velcro-like density-dependent targeting of cancer glycans

  • Post author:
  • Post published:May 20, 2025
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Continue ReadingGlyTR2 CAR T cell translation: safe pan-cancer killing via velcro-like density-dependent targeting of cancer glycans

FM-IL2 CAR T cells for Pancreatic Cancer

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  • Post published:May 20, 2025
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Continue ReadingFM-IL2 CAR T cells for Pancreatic Cancer

Development of an off-the-shelf iPSC derived CAR T cell therapy for the treatment of solid tumors

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  • Post published:May 20, 2025
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Continue ReadingDevelopment of an off-the-shelf iPSC derived CAR T cell therapy for the treatment of solid tumors

A Novel Gene Therapy to Target Glioblastoma via Custom-Engineered Adenovirus-Associated Viral Vectors

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  • Post published:May 20, 2025
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Continue ReadingA Novel Gene Therapy to Target Glioblastoma via Custom-Engineered Adenovirus-Associated Viral Vectors
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