CIRM Funded Clinical Trials

Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients

Disease Area:
HIV-related Lymphoma, HIV/AIDS
CIRM Grant:
CLIN2-08289 (Active)
Award Value:
Trial Stage:
Phase 1/2
Trial Status:
Active, not recruiting
Targeted Enrollment:
11 ID:


A team at UC Davis is taking a patient’s blood forming stem cells and inserting three anti-HIV genes into them and then returning them to the individual to help rebuild their immune system. The anti-HIV genes are then passed on to all new¬†immune system cells, which¬†makes them resistant to HIV. Because AIDS-related lymphoma is linked to the constant immune cell stimulation caused by HIV infection, getting rid of the virus should prevent return of the cancer.


Open label, single arm study.


Safety. Efficacy - immune reconstitution, viral load and HIV status.

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