CIRM Funded Clinical Trials

Phase I Treatment of Urethral Strictures in Humans

Disease Area:
Bladder or Urinary Tract Disorder
CIRM Grant:
CLIN2-13267 (Active)
Award Value:
Trial Sponsor:
Wake Forest University Health Sciences
Trial Stage:
Phase 1
Trial Status:
Not yet recruiting
Targeted Enrollment:
10 ID:


When a scar, or stricture, forms along the urethra it impedes the flow of urine and causes other complications. James Yoo, M.D., Ph.D., and his team at Wake Forest University Health Sciences will use epithelial and smooth muscle cells, taken from the patient’s bladder, and layer them on to a synthetic tubular scaffold. The tube will then be surgically implanted inside the urethra.

The goal is for the progenitor cells to support self-renewal of the tissue and for the entire structure to become integrated into the surrounding tissue and become indistinguishable from it, restoring normal urinary function. Dr. Yoo and his team believe their approach has the potential to be effective for at least a decade.

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