CIRM Funded Clinical Trials

A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC


Disease Area:
CIRM Grant:
CLIN2-10784 (Active)
Award Value:
$10,955,315.00
Trial Sponsor:
University of California, Los Angeles
Trial Stage:
Phase 1
Trial Status:
Active, not recruiting
Targeted Enrollment:
24
ClinicalTrials.gov ID:

Details:

The five-year survival rate for people diagnosed with the most advanced stage of non-small cell lung cancer (NSCLC) is between one and 10 percent.

To address this devastating condition, UCLA researchers are genetically modifying a patient’s own dendritic cells – key cells of the immune system – to boost their ability to stimulate native T cells – a type of white blood cell – to destroy cancer cells. 

The investigators will combine this cell therapy with the FDA-approved therapy pembrolizumab (better known as Keytruda) a therapeutic that renders cancer cells more susceptible to clearance by the immune system.

Design:

Dose escalation and expansion.

Goal:

Determination of maximum tolerated dose and objective response rate at selected dose in lung cancers.

News about this clinical trial:

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