Unraveling nuclear Tau functions using age-equivalent human induced neurons from healthy aging donors and tauopathy patients

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Research Objective This project investigates how normal tau protein protects aging neurons. We'll use aging human neurons to understand how tau helps repairing DNA and why this protection fails disease.…

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Generation of human airway stem cells by direct transcriptional reprogramming for disease modeling and regeneration

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Research Objective We will generate human airway stem cells by direct transcriptional reprogramming of fibroblasts. We will use these induced airway stem cells to model motile cilia disease in a…

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