iPSC-Derived Organs In Vivo: Challenges and Promise.

Journal: 
Cell Stem Cell
Publication Year: 
2018
Authors: 
Fabian Suchy
Tomoyuki Yamaguchi
Hiromitsu Nakauchi
PubMed link: 
29304339
Public Summary: 
In this paper, we discuss the clinical potential of generating solid organs from iPSCs using interspecies organogenesis. We describe the challenges and potential solutions in moving this basic research into a clinical treatment for patients.
Scientific Abstract: 
Transplanting iPSCs into the embryos of another species can generate functional organs for basic research and translational applications. We discuss forward-looking approaches and address key remaining challenges of generating iPSC-derived human organs in vivo.