Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

The complex intracellular signaling pathways that promote blood stem cell maintenance and growth are still poorly defined. Here, we used engineered signaling receptors to distinguish intracellular signaling pathways involved in blood stem cell proliferation. These findings will help to develop methods to expand blood stem cell ex vivo.