Unlocking the regenerative potential of hepatocyte plasticity for diseases of the biliary system
Grant Award Details
Grant Type:
Grant Number:
DISC0-18130
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$4,871,000
Status:
Pre-Active
Grant Application Details
Application Title:
Unlocking the regenerative potential of hepatocyte plasticity for diseases of the biliary system
Public Abstract:
Research Objective
The research will generate the know-how for replacing lost or injured bile ducts in the liver by reprogramming an abundant and related cell type that normally has a very different function.
Impact
Knowing how to generate bile ducts by reprogramming of other cell types would make a gene therapy for diseases possible that can currently only be cured by liver transplantation.
The research will generate the know-how for replacing lost or injured bile ducts in the liver by reprogramming an abundant and related cell type that normally has a very different function.
Impact
Knowing how to generate bile ducts by reprogramming of other cell types would make a gene therapy for diseases possible that can currently only be cured by liver transplantation.
