Identifying and Overcoming Roadblocks to Hearing Restoration Using Human Induced Pluripotent Stem Cells
Grant Award Details
Grant Type:
Grant Number:
DISC0-17674
Investigator(s):
Award Value:
$4,608,000
Status:
Pre-Active
Grant Application Details
Application Title:
Identifying and Overcoming Roadblocks to Hearing Restoration Using Human Induced Pluripotent Stem Cells
Public Abstract:
Research Objective
To utilize human iPSCs as an in vitro model of hearing loss and overcome obstacles to hair cell regeneration by prompting post-mitotic supporting cells to re-enter the cell cycle.
Impact
This research will help determine and overcome the molecular roadblocks to cochlear hair cell regeneration in humans, potentially informing new approaches to treat hearing loss.
To utilize human iPSCs as an in vitro model of hearing loss and overcome obstacles to hair cell regeneration by prompting post-mitotic supporting cells to re-enter the cell cycle.
Impact
This research will help determine and overcome the molecular roadblocks to cochlear hair cell regeneration in humans, potentially informing new approaches to treat hearing loss.
