IFN-γ suppresses AT2 cell regeneration to promote lung fibrosis
Grant Award Details
Grant Type:
Grant Number:
DISC0-17315
Investigator(s):
Award Value:
$4,525,190
Status:
Pre-Active
Grant Application Details
Application Title:
IFN-γ suppresses AT2 cell regeneration to promote lung fibrosis
Public Abstract:
Research Objective
We will determine how viral infections alter lung progenitor cells thereby impairing their ability to regenerate the lungs and in turn promoting lung fibrosis.
Impact
We will define mechanisms promoting fibrosis after viral infection. Our work will also provide information on the pathobiology of other types of lung fibrosis, such as idiopathic pulmonary fibrosis.
We will determine how viral infections alter lung progenitor cells thereby impairing their ability to regenerate the lungs and in turn promoting lung fibrosis.
Impact
We will define mechanisms promoting fibrosis after viral infection. Our work will also provide information on the pathobiology of other types of lung fibrosis, such as idiopathic pulmonary fibrosis.
