TSRI Center for hESC Research

TSRI Center for hESC Research

Funding Type: 
Shared Labs
Grant Number: 
CL1-00502-1.2
Award Value: 
$3,775,070
Stem Cell Use: 
Embryonic Stem Cell
iPS Cell
Status: 
Active
Public Abstract: 
Statement of Benefit to California: 
Progress Report: 

Year 1

The mission of the CIRM Shared Laboratory is to provide researchers with the resources to undertake pilot or long-term projects using stem cell technologies. These resources include basic training (each lab user must take a training course), advanced training and advice, and the use of high quality equipment. In addition to cell culture and cell biology facilities, our center has two unique features: high-throughput molecular profiling (Loring) and high throughput chemical screening (Ding). Each researcher, when qualified, supplies his or her own reagents and supplies, and works under the supervision of the dedicated staff. Cell lines used in the lab are tightly quality controlled.

Year 2

The mission of the CIRM Shared Laboratory is to provide researchers with the resources to undertake pilot or long-term projects using stem cell technologies. These resources include basic training (each lab user must take a training course), advanced training and advice, and the use of high quality equipment. In addition to cell culture and cell biology facilities, our center has two unique features: high-throughput molecular profiling (Loring) and high throughput chemical screening (Ding). This shared stem cell lab continues its success and has established itself as a local stem cell hub. Each researcher, when qualified, supplies his or her own reagents and supplies, and works under the supervision of the dedicated staff. In the past year, many researchers from labs locally and nationally continue to use our shared stem cell lab for independent research projects, or participate in the training courses as summarized in details in the report.

Year 3

The TSRI Shared Laboratory and Training Center serves the public by providing laboratory tours, public lectures, and special events for public education. New scientific collaborations were established in the past year and there are currently more than 40 active collaborations with local and international researchers. These groups published a remarkable 19 scientific papers last year. The center remains active in Cell Biology, Genomics, and High-Throughput Screening (HTS). Improvements have been to the Chemical Screening Facility which provides a more user friendly space. The equipment is in constant use, and new collaborators are learning how to use HTS and Chemical Screening in their studies. The training courses now include training in induced pluripotent stem cell technology. The courses included training for several Bridges to Stem Cell Research groups, local graduate students, postdoctoral fellows, and a group of researchers from the NIH’s Chemical Screening Center. We plan to maintain our level of involvement with the public, and will participate in events organized by interested lay people.

Year 4

The TSRI Shared Laboratory and Training Center serves the public by providing laboratory tours, public lectures, and special events for public education. New scientific collaborations were established in the past year and there are currently more than 45 active collaborations with local and international researchers. These groups published a remarkable number of scientific papers last year. The center remains active in Cell Biology, Genomics, and High-Throughput Screening (HTS). The training courses now include training in induced pluripotent stem cell technology. The courses included training for several Bridges to Stem Cell Research groups, local graduate students, and postdoctoral fellows. We plan to maintain our level of involvement with the public, and will participate in events organized by interested lay people.

Year 5

The TSRI Shared Laboratory and Training Center serves the scientific community with cutting edge technology and training, and serves the public by providing laboratory tours, public lectures, and special events for public education. New scientific collaborations were established in the past year and there are currently more than 45 active collaborations with local and international researchers. These groups were remarkably productive in their research, publishing scientific results in many top-tier scientific journals. We have also been able to leverage the shared lab infrastructure to attract additional funding. In our five years of funding, the shared lab infrastructure has facilitated approximately $33 million in outside funding from the NIH, foundations, and philanthropy, which is more than thirteen-fold the investment made in the shared labs by CIRM. The center remains active in Cell Biology, Genomics, and High-Throughput Screening (HTS). The training courses now include training in induced pluripotent stem cell technology. The courses included training for several Bridges to Stem Cell Research groups, local graduate students, and postdoctoral fellows. We plan to maintain our level of involvement with the public, and will participate in events organized for and by interested lay people.

© 2013 California Institute for Regenerative Medicine