Research Objective We propose to apply scalable platforms for the characterization of CNVs and genes coupled with detailed characterizations of neurodevelopment of the 4 major CNV loci in model systems…
Research Objective We will uncover pathways through which ASD mutations cause disease and close the gap from disease research to therapeutic testing using organoids, primary human neurons, machine learning and…
We propose to expand and enhance our stem cell core, a key resource for the local area.This project will accelerate new therapies and train stem cell scientists. We propose to…
This proposal will create a laboratory that will provide training in advanced stem cell modeling technology, particularly organ chip technology. This laboratory aims to train stem cell researchers in using…
The goal of this project is to support the discovery and evaluation of novel therapeutics using stem cell-based models and drug and CRISPR screening. The facility will provide California researchers…
This project enhances stem cell access, scalability, and collaboration. It offers characterized hPSC lines, CRISPR editing, and differentiation on automated platforms accelerating progress in biology, disease research, and regenerative medicine.…
The proposed CIRM ASCEND Center provides cutting-edge organoid-based services, offering consultation, optimized protocols, and genomic analysis. We also offer comprehensive training, workshops, and access to data, empowering researchers across California…
Our broad objective is to expand access to equipment, services, and training within our areas of excellence. Through knowledge sharing and collaboration, we aim to add value to the CIRM…
Use of stem cells in human disease modeling has reached a broader scientific audience of underserved, marginalized communities. Researchers/scholars have comprehensive training in iPSC generation, genetic modification, and differentiation techniques…
The areas of focus for our SRL will include induced pluripotent stem cell generation and characterization, cell differentiation and generation of a microvascular tissue model and in vivo models. Our…
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