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Long noncoding RNAs for pluripotency and cell fate commitment

  • Post author:
  • Post published:June 5, 2025
  • Post category:

The human body is composed of thousands of cell types, which all came originally from embryonic stem cells. Although all these cell types have the same genetic blueprint, different genes…

Continue ReadingLong noncoding RNAs for pluripotency and cell fate commitment

Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State

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  • Post published:June 5, 2025
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A subset of intellectual disability cases in humans are caused by mutations in an X-linked gene essential for a quality control mechanism called nonsense-mediated RNA decay (NMD). Patients with mutations…

Continue ReadingRole of the NMD RNA Decay Pathway in Maintaining the Stem-Like State

Studying Arrhythmogenic Right Ventricular Dysplasia with patient-specific iPS cells

  • Post author:
  • Post published:June 5, 2025
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Most heart conditions leading to sudden death or impaired pumping heart functions in the young people (

Continue ReadingStudying Arrhythmogenic Right Ventricular Dysplasia with patient-specific iPS cells

Mechanisms to protect hESC-derived cells from allogenic immune rejection

  • Post author:
  • Post published:June 5, 2025
  • Post category:

The potential of human embryonic stem cells (hESC) to differentiate into a tremendous range of biologically active cells/tissues is the basis for many novel therapeutic strategies. However, immune-mediated rejection of…

Continue ReadingMechanisms to protect hESC-derived cells from allogenic immune rejection

Modeling Alexander disease using patient-specific induced pluripotent stem cells

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  • Post published:June 5, 2025
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Alexander disease (AxD) is a devastating childhood disease that affects neural development and causes mental retardation, seizures and spasticity. The most common form of AxD occurs during the first two…

Continue ReadingModeling Alexander disease using patient-specific induced pluripotent stem cells

Mechanism of heart regeneration by cardiosphere-derived cells

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  • Post published:June 5, 2025
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In the process of a heart attack, clots form suddenly on top of cholesterol-laden plaques, blocking blood flow to heart muscle. As a result, living heart tissue dies and is…

Continue ReadingMechanism of heart regeneration by cardiosphere-derived cells

Deciphering transcriptional control of pancreatic beta-cell maturation in vitro

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  • Post published:June 5, 2025
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The loss of pancreatic beta-cells in type 1 diabetes results in absence of insulin secreted by the pancreas, and consequently elevated blood sugar which leads to various long-term complications. Diabetic…

Continue ReadingDeciphering transcriptional control of pancreatic beta-cell maturation in vitro

DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION.

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  • Post published:June 5, 2025
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Hematopoietic stem cells (HSCs) are an important population of cells that continuously produce and replace blood and immune cells over the course of our lifetimes. These rare, self-renewing cells are…

Continue ReadingDECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION.

Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells

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  • Post published:June 5, 2025
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Progress from our group and others has led to the identification of normal prostate tissue stem cells and the definition of important signaling pathways that regulate their growth and maintenance.…

Continue ReadingTrop2 dependent and independent mechanisms of self-renewal in human cancer stem cells

Phenotyping Human Astrocytes in Health and Disease

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  • Post published:June 5, 2025
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An emerging theme from recent research is that autism and schizophrenia are diseases of synapses, the interconnections through which electrical signals are relayed from one neuron to the next neuron…

Continue ReadingPhenotyping Human Astrocytes in Health and Disease
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