Year 5

As a result of this CIRM award, we have been able to develop 3D human models of cardiac and neural tissues derived from pluripotent stem cell sources. These systems are currently being used to study mechanisms of human tissue biology in culture that can not be done using existing animal models or other alternative systems. Furthermore, these stem cell-derived tissues are now being used to study the impacts of genome editing outcomes, which will allow safety and efficacy testing in the future