Year 4

The primary goals of our CIRM-funded research are to investigate the mechanisms of stem cell proliferation and refractoriness in adult and embryonic stem cells. Our focus has been on pathways that are functionally important to stem cell proliferation that are targetable by small molecules or by approaches that are unlikely to cause DNA damage. The outcome of such research may be the identification of targetable pathways in activating or suppressing stem cell proliferation during organ regeneration.