The CIRM Human Pluripotent Stem Cell Biorepository, operated by the Coriell Institute for Medical Research, is a critical component of the CIRM hPSC Initiative. The goal of the Initiative was to generate high quality disease-specific human pluripotent stem cells. These iPSCs are intented to be used by world-wide non-profit and for-profit entities, for disease modeling and drug discovery and development in prevalent, genetically complex diseases.
As of the end of Year 4, submissions from 2,835 subjects have been received from ten submitting groups and banked at Coriell. To this date, 1,835 P10 Distribution Bank samples and 2,259 P5 Master Bank clones have been generated by Cellular Dynamics International (CDI) and stored at Coriell. At the end of Year 4, 1,547 samples are available for distribution through Coriell’s online catalog. For samples to be available for distribution, clinical data must be completed and reviewed by Coriell staff. The catalog includes Disease specific pages, an Advanced Clinical Data Search, as well as all documents (Material Transfer Agreement and Licensing Agreements) needed to complete an order.